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Tuesday, February 2, 2010

The puzzle of HIV AIDS Drugs Began to Lift

Tuesday, February 2, 2010
Since the beginning of AIDS epidemic nearly 60 million people have been infected with HIV and 25 million people died related to HIV. Although the combination of several drugs can make patients still look healthy, but until now there is no vaccine or medicine that can cure this disease. Data of the United Nations in the year 2008 there were 33.4 million people infected with HIV and 2 million of whom died of AIDS.

Scientists began to solve an important puzzle about HIV / AIDS. Research over the past 20 years has led to the discovery of better treatments for people living with HIV.

British researchers and the United States has managed to grow a crystal that allows researchers to see the structure of an enzyme called integrase. This enzyme is found in retroviruses such as HIV and is a target for a new HIV drug.

Scientists from Imperial and Harvard announced that it has successfully had the structure of the integrase of the virus. This means that researchers can begin to understand how the work of the integrase inhibitor drugs and how to stop the development of HIV / AIDS.

In the Nature journal, Cherepanov explains when human immunodeficiency virus (HIV) infected a person, virus uses the integrase enzyme to insert copies of genetic information in DNA of that person.

Some new drugs like Isentress for HIV from Merck & Co. and Elvitegravir (experimental drug from Gilead Sciences) works by blocking integrase. But the scientists do not know exactly how the work of the integrase and how to fix it. The only way to know is to get high-quality crystals.

It takes more than 40,000 tests in order to obtain a high-quality crystals that allows researchers to view three-dimensional structure. Researchers made crystals by using loans from the retroviral integrase similar to HIV. Researchers examining crystals from Merck medicines and Gilead in order to see how these drugs bind and inhibit integrase work.


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